Article
Adoptive transfer of heme oxygenase-1 (HO-1)-modified macrophages rescues the nuclear factor erythroid 2-related factor (Nrf2) antiinflammatory phenotype in liver ischemia/reperfusion injury.
Molecular medicine (Cambridge, Mass.) - 14 Oct 2014
Huang Jing, Shen Xiu-Da, Yue Shi, Zhu Jianjun, Gao Feng, Zhai Yuan, Busuttil Ronald W, Ke Bibo, Kupiec-Weglinski Jerzy W
Abstract excerpt
Macrophages are instrumental in the pathophysiology of liver ischemia/reperfusion injury (IRI). Although Nrf2 regulates macrophage-specific heme oxygenase-1 (HO-1) antioxidant defense, it remains unknown whether HO-1 induction might rescue macrophage Nrf2-dependent antiinflammatory functions. This study explores the mechanisms by which the Nrf2-HO-1 axis regulates sterile hepatic inflammation responses after...
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