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Article

Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis.

Journal of hepatology - 1 Jul 2012

Leroux Anne, Ferrere Gladys, Godie Vanessa, Cailleux Frédéric, Renoud Marie-Laure, Gaudin Françoise, Naveau Sylvie, Prévot Sophie, Makhzami Samira, Perlemuter Gabriel, Cassard-Doulcier Anne-Marie

Abstract excerpt

BACKGROUND & AIMS: Non-alcoholic steatohepatitis (NASH) is characterized by steatosis associated with liver inflammation. Steatosis causes recruitment of lymphocytes into the liver and this is worsened by lipopolysaccharides (LPS). As macrophages may be involved in the lymphocyte homing, we studied the role of lipids in determining the phenotype of Kupffer cells (KCs) at the stage of steatosis. METHODS: Steatosis...

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Identifiers

PMID: 22425624
DOI: 10.1016/j.jhep.2012.02.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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