Article
Genetic variants with gene regulatory effects are associated with diisocyanate-induced asthma.
The Journal of allergy and clinical immunology - 1 Sept 2018
Bernstein David I, Lummus Zana L, Kesavalu Banu, Yao Jianbo, Kottyan Leah, Miller Daniel, Cartier André, Cruz Maria-Jesús, Lemiere Catherine, Muñoz Xavier, Quirce Santiago, Tarlo Susan, Sastre Joaquin, Boulet Louis Philippe, Weirauch Matthew T, Kaufman Kenneth
Abstract excerpt
BACKGROUND: Isocyanates are major causes of occupational asthma, but susceptibility and mechanisms of diisocyanate-induced asthma (DA) remain uncertain. OBJECTIVE: The aim of this study was to identify DA-associated functional genetic variants through next-generation sequencing (NGS), bioinformatics, and functional assays. METHODS: NGS was performed in 91 workers with DA. Fourteen loci with known DA-associated...
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