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Article

CTNNA3 (α-catenin) gene variants are associated with diisocyanate asthma: a replication study in a Caucasian worker population.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jan 2013

Bernstein David I, Kashon Michael, Lummus Zana L, Johnson Victor J, Fluharty Kara, Gautrin Denyse, Malo Jean-Luc, Cartier André, Boulet Louis-Philippe, Sastre Joaquin, Quirce Santiago, Germolec Dori, Tarlo Susan M, Cruz Maria-Jesus, Munoz Xavier, Luster Michael I, Yucesoy Berran

Abstract excerpt

Recently, a genome-wide association study (GWAS) conducted in Korean subjects identified four CTNNA3 (alpha-T catenin) single nucleotide polymorphisms (SNPs) (rs10762058, rs7088181, rs1786929, and rs4378283) associated with diisocyanate-induced occupational asthma (DA). The CTNNA3 gene codes for a cadherin involved in formation of stretch-resistant cell-cell adhesions. We conducted a candidate gene association...

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Identifiers

PMID: 22977168
DOI: 10.1093/toxsci/kfs272
PMCID: PMC3537126

Genes

CTNNA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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