Article
Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Feb 2009
Kim S-H, Cho B-Y, Park C-S, Shin E-S, Cho E-Y, Yang E-M, Kim C-W, Hong C-S, Lee J-E, Park H-S
Abstract excerpt
BACKGROUND: Toluene diisocyanate (TDI) is the most important cause of occupational asthma, but the genetic mechanism of TDI-induced asthma is still unknown. OBJECTIVE: The objective of the study was to identify susceptibility alleles associated with the TDI-induced asthma phenotype. METHODS: We conducted a genome-wide association study in 84 patients with TDI-induced asthma and 263 unexposed healthy normal...
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