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Article

Interferon-γ Promoter Is Hypermethylated in Blood DNA from Workers with Confirmed Diisocyanate Asthma

27 Mar 2013

Abstract excerpt

Risk factors have not been identified that determine susceptibility for development of diisocyanate-induced occupational asthma (DA). We hypothesized that diisocyanate (DI) exposure could modify gene promoter regions regulating transcription of cytokine mediators and thereby influence expression of DA. A cross-sectional study was designed to investigate the promoter methylation status of candidate genes in...

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PMID: 23535363
DOI: 10.1093/toxsci/kft079

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