Article
Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma.
Journal of immunotoxicology - 1 Jan 2016
Yucesoy Berran, Kashon Michael L, Johnson Victor J, Lummus Zana L, Fluharty Kara, Gautrin Denyse, Cartier André, Boulet Louis-Philippe, Sastre Joaquin, Quirce Santiago, Tarlo Susan M, Cruz Maria-Jesus, Munoz Xavier, Luster Michael I, Bernstein David I
Abstract excerpt
Diisocyanates are the most common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants in inflammatory response genes (TNFα, IL1α, IL1β, IL1RN, IL10, TGFB1, ADAM33, ALOX-5, PTGS1, PTGS2 and NAG-1/GDF15) are associated with increased susceptibility to diisocyanate asthma (DA). These genes were selected based on their role in...
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