Article

Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq data

2023-05-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Despite well-documented effects on human health, the action modes of environmental pollutants are incompletely understood. Although transcriptome-based approaches are widely used to predict associations between chemicals and disorders, the molecular cues regulating pollutant-derived gene expression changes remain unclear. Therefore, we developed a data-mining approach, terme...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70383023-df42-5133-9005-8240ebfbfda8
DOI: 10.1101/2023.05.18.541391

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq dataDOI 10.1101/2023.05.18.541391Read

ToxiTaRGET: a multi-omics resource for toxicant-responsive molecular targetsSemantic proximity Read

CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health.Semantic proximity Read

Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases.Semantic proximity Read

E.PAGE: A curated database and enrichment tool to predict gene modules associated with gene-environment interactionsSemantic proximity Read

Integrating genomic and exposomic data identifies endocrine disruptors potentially associated with chronic obstructive pulmonary disease.Semantic proximity Read

Comprehensive Transcriptomic and Epigenomic Insights into Environmental Toxicant Exposures: The TaRGET II ResourceSemantic proximity Read

Toxicogenomic Insights into Environmental Toxicant Exposures: The TaRGET II ResourceSemantic proximity Read

Environmental exposures and gene regulation in disease etiology.Semantic proximity Read

Immune–Epigenetic Effects of Environmental Pollutants: Mechanisms, Biomarkers, and Transgenerational ImpactSemantic proximity Read

A comprehensive data repository of environmental toxicants exposed mouse epigenomes from the TaRGET II ConsortiumSemantic proximity Read

Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways.Semantic proximity Read

Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database.Semantic proximity Read