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Article

Toluene diisocyanate exposure and autotaxin-lysophosphatidic acid signalling.

Toxicology and applied pharmacology - 15 Sept 2018

Broström Julia M, Ghalali Aram, Zheng Huiyuan, Högberg Johan, Stenius Ulla, Littorin Margareta, Tinnerberg Håkan, Broberg Karin

Abstract excerpt

Toluene diisocyanate (TDI) is a reactive chemical used in manufacturing plastics. TDI exposure adversely affects workers' health, causing occupational asthma, but individuals differ in susceptibility. We recently suggested a role for signalling mediated by the enzyme autotaxin (ATX) and its product, lysophosphatidic acid (LPA), in TDI toxicity. Here we genotyped 118 TDI-exposed workers for six single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29940203
DOI: 10.1016/j.taap.2018.06.019

Genes

LPA
CAV1
CCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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