Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.

doi:10.1097/JOM.0000000000000138

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Article

Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.

Journal of occupational and environmental medicine - 1 Apr 2014

Yucesoy Berran, Johnson Victor J, Lummus Zana L, Kashon Michael L, Rao Marepalli, Bannerman-Thompson Hansen, Frye Bonnie, Wang Wei, Gautrin Denyse, Cartier André, Boulet Louis-Philippe, Sastre Joaquin, Quirce Santiago, Tarlo Susan M, Germolec Dori R, Luster Michael I, Bernstein David I

Abstract excerpt

OBJECTIVE: To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA). METHODS: The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels. RESULTS: The HLA-E rs1573294 and HLA-DPB1...

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PMID: 24709764
DOI: 10.1097/JOM.0000000000000138
PMCID: PMC4572490

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