Article
Diisocyanate asthma and gene-environment interactions with IL4RA, CD-14, and IL-13 genes.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 Dec 2006
Bernstein David I, Wang Ning, Campo Paloma, Chakraborty Ranajit, Smith Andrew, Cartier André, Boulet Louis-Philippe, Malo Jean-Luc, Yucesoy Berran, Luster Michael, Tarlo Susan M, Hershey Gurjit K Khurana
Abstract excerpt
BACKGROUND: Diisocyanate asthma (DA) affects 2% to 10% of exposed workers, yet the pathogenetic mechanisms underlying this disorder remain ill defined. OBJECTIVE: To determine if specific single nucleotide polymorphisms (SNPs) of interleukin 4 receptor alpha (IL4RA), IL-13, and CD14 promoter gene...
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