Article
Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2012
Yucesoy Berran, Johnson Victor J, Lummus Zana L, Kissling Grace E, Fluharty Kara, Gautrin Denyse, Malo Jean-Luc, Cartier André, Boulet Louis-Philippe, Sastre Joaquin, Quirce Santiago, Germolec Dori R, Tarlo Susan M, Cruz Maria-Jesus, Munoz Xavier, Luster Michael I, Bernstein David I
Abstract excerpt
Diisocyanates are a common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants of antioxidant defense genes, glutathione S-transferases (GSTM1, GSTT1, GSTM3, GSTP1), manganese superoxide dismutase (SOD2), and microsomal epoxide hydrolase (EPHX1) are associated with increased susceptibility to diisocyanate-induced asthma...
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