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Article

Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2018

Hirsch Daniela, Wangsa Darawalee, Zhu Yuelin J, Hu Yue, Edelman Daniel C, Meltzer Paul S, Heselmeyer-Haddad Kerstin, Ott Claudia, Kienle Peter, Galata Christian, Horisberger Karoline, Ried Thomas, Gaiser Timo

Abstract excerpt

Purpose: Patients with inflammatory bowel diseases, that is, ulcerative colitis and Crohn's disease (CD), face an increased risk of developing colorectal cancer (CRC). Evidence, mainly from ulcerative colitis, suggests that TP53 mutations represent an initial step in the progression from inflamed colonic epithelium to CRC. However, the pathways involved in the evolution of CRC in patients with CD are poorly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29967250
DOI: 10.1158/1078-0432.CCR-18-0630
PMCID: PMC8080970

Genes

APC
KRAS
SMAD2
SMAD3

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