Article
Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease.
Gastroenterology - 1 Aug 2016
Yaeger Rona, Shah Manish A, Miller Vincent A, Kelsen Judith R, Wang Kai, Heins Zachary J, Ross Jeffrey S, He Yuting, Sanford Eric, Yantiss Rhonda K, Balasubramanian Sohail, Stephens Philip J, Schultz Nikolaus, Oren Moshe, Tang Laura, Kelsen David
Abstract excerpt
BACKGROUND & AIMS: Patients with inflammatory bowel diseases, such as Crohn's disease (CD) and ulcerative colitis (UC), are at increased risk for small bowel or colorectal cancers (colitis-associated cancers [CACs]). We compared the spectrum of genomic alterations in CACs with those of sporadic colorectal cancers (CRCs) and investigated differences between CACs from patients with CD vs UC. METHODS: We studied...
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