Article

Human <i>trans</i> -editing enzyme displays tRNA acceptor stem specificity and relaxed amino acid selectivity

2020-09-11

Abstract excerpt

Accurate translation of genetic information into proteins is vital for cell sustainability. ProXp-ala prevents proteome-wide Pro-to-Ala mutations by hydrolyzing misacylated Ala-tRNA Pro , which is synthesized by prolyl-tRNA synthetase (ProRS). Bacterial ProXp-ala was previously shown to combine a size-based exclusion mechanism with conformational and chemical selection for the recognition of the alanyl moiety, wh...

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Literature Corpus work: 51f9fff2-c259-53b8-9e5b-057587182b38
DOI: 10.1101/2020.09.11.293571

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