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Article

Leu33Pro (PlA) polymorphism of integrin beta3 modulates platelet Src pY418 and focal adhesion kinase pY397 phosphorylation in response to abnormally high shear stress.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Sept 2018

Huynh Khon, Nguyen Thi-Hiep, Nguyen Phuong Thao, Tran Ngoc Quyen, Vo Van Toi, Gyenes Marianna, Stoldt Volker R

Abstract excerpt

OBJECTIVES: Shear stress can activate platelet integrin-mediated signaling that leads to shear-induced platelet aggregation (SIPA) and eventually contribute to acute myocardial infarction. The major platelet integrin αIIbβ3 is polymorphic at residue 33 [Leu33Pro (PlA) polymorphism]. The Pro33 isoform has been shown to have a prothrombotic phenotype. In this work, we studied the impact of Leu33/Pro33 polymorphism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29965811
DOI: 10.1097/MBC.0000000000000744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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