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Article

The Pl(A2) polymorphism of integrin beta(3) enhances outside-in signaling and adhesive functions.

The Journal of clinical investigation - 1 Mar 2000

Vijayan K V, Goldschmidt-Clermont P J, Roos C, Bray P F

Abstract excerpt

Genetic factors are believed to influence the development of arterial thromboses. Because integrin alpha(IIb)beta(3) plays a crucial role in thrombus formation, we analyzed receptor adhesive properties using Chinese hamster ovary and human kidney embryonal 293 cells overexpressing the Pl(A1) or Pl(A2) polymorphic forms of alpha(IIb)beta(3). Soluble fibrinogen binding was no different between Pl(A1) and Pl(A2)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10727448
DOI: 10.1172/JCI6982
PMCID: PMC377456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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