Article
Defects in Glanzmann thrombasthenia and LAD-III (LAD-1/v) syndrome: the role of integrin β1 and β3 in platelet adhesion to collagen.
Blood - 12 Jan 2012
van de Vijver Edith, De Cuyper Iris M, Gerrits Anja J, Verhoeven Arthur J, Seeger Karl, Gutiérrez Laura, van den Berg Timo K, Kuijpers Taco W
Abstract excerpt
Patients with Glanzmann thrombasthenia or Leukocyte Adhesion Deficiency-III syndrome (LAD-III or LAD-1/variant) present with increased bleeding tendency because of the lack or dysfunction of the fibrinogen receptor GPIIb/IIIa (integrin αIIbβ3), respectively. Although the bleeding disorder is more severe in LAD-III patients, classic aggregometry or perfusion of Glanzmann or LAD-III platelets over collagen-coated...
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