TLR7 polymorphism, sex and chronic HBV infection influence plasmacytoid DC maturation by TLR7 ligands.

doi:10.1016/j.antiviral.2018.06.015

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Article

TLR7 polymorphism, sex and chronic HBV infection influence plasmacytoid DC maturation by TLR7 ligands.

Antiviral research - 1 Sept 2018

Buschow Sonja I, Biesta Paula J, Groothuismink Zwier M A, Erler Nicole S, Vanwolleghem Thomas, Ho Erwin, Najera Isabel, Ait-Goughoulte Malika, de Knegt Robert J, Boonstra Andre, Woltman Andrea M

Abstract excerpt

TLR7 agonists are of high interest for the treatment of cancer, auto-immunity and chronic viral infections. They are known to activate plasmacytoid dendritic cells (pDCs) to produce high amounts of Type I Interferon (IFN) and to facilitate T and B cell responses, the latter with the help of maturation markers such as CD40, CD80 and CD86. The TLR7 single nucleotide polymorphism (SNP) rs179008 (GLn11Leu), sex and...

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Identifiers

PMID: 29964062
DOI: 10.1016/j.antiviral.2018.06.015

Genes

TLR7
TLR9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.