Article
Sex Differences in Primary HIV Infection: Revisiting the Role of TLR7-Driven Type 1 IFN Production by Plasmacytoid Dendritic Cells in Women.
Frontiers in immunology - 1 Jan 2021
Guéry Jean-Charles
Abstract excerpt
Plasmacytoid dendritic cells (pDCs) produce type I interferon (IFN-I) during HIV-1 infection in response to TLR7 stimulation. However, IFN-I-signaling has been shown to play opposite effects in HIV-1 and SIV infection. TLR7-driven type I interferon production in pDCs is higher in women than in men due to the cell-intrinsic actions of estrogen and X-chromosome complement. Indeed, TLR7 is encoded on the...
Topics
- Animals
- Dendritic Cells
- Female
- HIV Infections
- HIV-1
- Host-Pathogen Interactions
- Humans
- Immunity, Innate
- Interferon Type I
- Male
- Polymorphism, Single Nucleotide
- Protective Factors
- Risk Factors
- Sex Characteristics
- Sex Factors
- Signal Transduction
- Toll-Like Receptor 7
- Viral Load