Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19

11 Nov 2021

Abstract excerpt

A male sex bias has emerged in the COVID-19 pandemic, fitting to the sex-biased pattern in other viral infections. Males are 2.84 times more often admitted to the ICU and mortality is 1.39 times higher as a result of COVID-19. Various factors play a role in this, and novel studies suggest that the gene-dose of Toll-Like Receptor (TLR) 7 could contribute to the sex-skewed severity. TLR7 is one of the crucial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Inflammasome and immune disorders
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34858409
DOI: 10.3389/fimmu.2021.756262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19PMID 34858409Read ↗

Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsSemantic proximity Read ↗

Sex-dependent immune response and lethality of COVID-19Semantic proximity Read ↗

The Role of Genetic Sex and Mitochondria in Response to COVID-19 InfectionSemantic proximity Read ↗

SeXX and COVID-19: Tussle between the TwoSemantic proximity Read ↗

Gender Specific Differences in Disease Susceptibility: The Role of EpigeneticsSemantic proximity Read ↗

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.Semantic proximity Read ↗

The X-files in immunity: sex-based differences predispose immune responses.Semantic proximity Read ↗

COVID-19 Pandemic: Insights into Molecular Mechanisms Leading Sex-based Differences in Patient OutcomesSemantic proximity Read ↗

What's Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses.Semantic proximity Read ↗

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in malesSemantic proximity Read ↗

Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patientsSemantic proximity Read ↗

Sex Differences in Immune Responses to Infectious Diseases: The Role of Genetics, Hormones, and AgingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.