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Article

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

Human molecular genetics - 15 Jun 2003

Corti Olga, Hampe Cornelia, Koutnikova Hana, Darios Frédéric, Jacquier Sandrine, Prigent Annick, Robinson Jean-Charles, Pradier Laurent, Ruberg Merle, Mirande Marc, Hirsch Etienne, Rooney Thomas, Fournier Alain, Brice Alexis

Abstract excerpt

Parkinson's disease (PD) is a severe neurological disorder, characterized by the progressive degeneration of the dopaminergic nigrostriatal pathway and the presence of Lewy bodies (LBs). The discovery of genes responsible for familial forms of the disease has provided insights into its pathogenesis. Mutations in the parkin gene, which encodes an E3 ubiquitin-protein ligase involved in the ubiquitylation and...

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Identifiers

PMID: 12783850
DOI: 10.1093/hmg/ddg159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.PMID 12783850Read ↗

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