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Article

GTP-binding facilitates EB1 recruitment onto microtubules by relieving its auto-inhibition.

Scientific reports - 28 Jun 2018

Gireesh K K, Shine A, Lakshmi R Bhagya, Vijayan Vinesh, Manna Tapas K

Abstract excerpt

Microtubule plus end-binding protein, EB1 is a key regulator of microtubule dynamics. Auto-inhibitory interaction in EB1 has previously been shown to inhibit its ability to bind to microtubules and regulate microtubule dynamics. However, the factors that promote its microtubule regulatory activity by over-coming the auto-inhibition are less known. Here, we show that GTP plays a critical role in promoting the...

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Identifiers

PMID: 29955158
DOI: 10.1038/s41598-018-28056-y
PMCID: PMC6023887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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