Article
Role of Macrophage Migration Inhibitory Factor in Granulomatosis With Polyangiitis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Dec 2018
Sreih Antoine G, Ezzedine Rana, Leng Lin, Fan Juan, Yao Jie, Reid Duncan, Piecychna Marta, Carette Simon, Cuthbertson David, Dellaripa Paul, Hoffman Gary S, Khalidi Nader A, Koening Curry L, Langford Carol A, Mahr Alfred, McAlear Carol A, Maksimowicz-Mckinnon Kathleen, Monach Paul A, Seo Philip, Specks Ulrich, St Clair E William, Stone John H, Ytterberg Steven R, Edberg Jeffrey, Merkel Peter A, Bucala Richard
Abstract excerpt
OBJECTIVE: To examine the association between macrophage migration inhibitory factor (MIF) promoter polymorphisms and granulomatosis with polyangiitis (GPA) in human subjects, and to assess the role of MIF in a murine model of granulomatous vasculitis. METHODS: The human study involved 1,077 patients with GPA and healthy controls whose serum was genotyped by capillary electrophoresis for the MIF -794 CATT5-8...
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