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Article

Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus.

Arthritis and rheumatism - 1 Dec 2011

Sreih Antoine, Ezzeddine Rana, Leng Lin, LaChance Avery, Yu Geraldine, Mizue Yuka, Subrahmanyan Lakshman, Pons-Estel Bernardo A, Abelson Anna-Karin, Gunnarsson Iva, Svenungsson Elisabet, Cavett Joshua, Glenn Stuart, Zhang Lin, Montgomery Ruth, Perl Andras, Salmon Jane, Alarcón-Riquelme Marta E, Harley John B, Bucala Richard

Abstract excerpt

OBJECTIVE: To study the effect of the innate cytokine macrophage migration inhibitory factor (MIF) on the susceptibility and severity of systemic lupus erythematosus (SLE) in a multinational population of 1,369 Caucasian and African American patients. METHODS: Two functional polymorphisms in the MIF gene, a -794 CATT(5-8) microsatellite repeat (rs5844572) and a -173 G/C single-nucleotide polymorphism (rs755622),...

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Source

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Identifiers

PMID: 22127710
DOI: 10.1002/art.30624
PMCID: PMC3228269

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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