Genotyping Two Promoter Polymorphisms in the MIF Gene: A -794 CATT5-8 Microsatellite Repeat and a -173 G/C SNP.

doi:10.1007/978-1-4939-9936-1_7

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Genotyping Two Promoter Polymorphisms in the MIF Gene: A -794 CATT5-8 Microsatellite Repeat and a -173 G/C SNP.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Leng Lin, Siu Edwin, Bucala Richard

Abstract excerpt

Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. The promoter region of the human MIF gene contains two polymorphisms. A variable nucleotide tandem repeat at position -794 comprises five to eight CATT repeats (referred to henceforth by numbers from 5 to 8, rs5844572). Gene reporter assays show a proportional increase in transcription...

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PMID: 31745872
DOI: 10.1007/978-1-4939-9936-1_7

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