A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease.

doi:10.1096/fj.11-195065

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Article

A functional microsatellite of the macrophage migration inhibitory factor gene associated with meningococcal disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2012

Renner Pascal, Roger Thierry, Bochud Pierre-Yves, Sprong Tom, Sweep Fred C G J, Bochud Murielle, Faust Saul N, Haralambous Elene, Betts Helen, Chanson Anne-Laure, Reymond Marlies Knaup, Mermel Elliot, Erard Veronique, van Deuren Marcel, Read Robert C, Levin Michael, Calandra Thierry

Abstract excerpt

Macrophage migration inhibitory factor (MIF) is an abundantly expressed proinflammatory cytokine playing a critical role in innate immunity and sepsis and other inflammatory diseases. We examined whether functional MIF gene polymorphisms (-794 CATT(5-8) microsatellite and -173 G/C SNP) were associated with the occurrence and outcome of meningococcal disease in children. The CATT(5) allele was associated with the...

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PMID: 21990375
DOI: 10.1096/fj.11-195065

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