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Article

Role for macrophage migration inhibitory factor in asthma.

Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2005

Mizue Y, Ghani S, Leng L, McDonald C, Kong P, Baugh J, Lane S J, Craft J, Nishihira J, Donnelly S C, Zhu Z, Bucala R

Abstract excerpt

Macrophage migration inhibitory factor (MIF) is an immunologic regulator that is expressed in inflammatory and autoimmune disorders. We investigated MIF's role in asthma using genetic approaches in a mouse model and in a cohort of asthma patients. Mice genetically deficient in MIF that were primed and aerosol-challenged with ovalbumin showed less pulmonary inflammation and lower airway hyperresponsiveness than...

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Source

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Identifiers

PMID: 16186482
DOI: 10.1073/pnas.0507189102
PMCID: PMC1242335

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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