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Article

CD8+ T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress.

Journal of virology - 1 Sept 2018

Zhang Yu, Wu Yan, Deng Mengmeng, Xu Dongping, Li Xiaodong, Xu Zhihui, Hu Jun, Zhang Han, Liu Kefang, Zhao Yingze, Gao Feng, Bi Shengli, Gao George F, Zhao Jingmin, Liu William J, Meng Songdong

Abstract excerpt

Under the immune pressure of cytotoxic T cells (CTLs), hepatitis B virus (HBV) evolves to accumulate mutations more likely within epitopes to evade immune detection. However, little is known about the specific patterns of the immune pressure-associated HBV mutation of T-cell epitopes and their link to disease progression. Here, we observed a correlation of the accumulated variants on HBV core protein (HBc) with...

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Topics

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Share to Epitopes, T-Lymphocyte
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B Core Antigens

Share to Mutation

Share to Selection, Genetic

Share to Sequence Analysis, DNA

Share to T-Lymphocytes

Source

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Identifiers

PMID: 29950410
DOI: 10.1128/JVI.02120-17
PMCID: PMC6096822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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