Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Number of mutations within CTL‐defined epitopes of the hepatitis B Virus (HBV) core region is associated with HBV disease progression

19 Oct 2011

Abstract excerpt

The virologic determinants of progressive liver disease associated with hepatitis B virus (HBV) remain unclear. Previous investigations have associated HBV disease with specific mutations but this association may be confounded by HBV genotype, HLA haplotype of the infected individual or both. The association between non-synonymous mutations located within putative cytotoxic T-lymphocyte directed epitopes (CDE) of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to Hepatitis C virus research
Share to Liver Disease Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22012714
DOI: 10.1002/jmv.22226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Number of mutations within CTL‐defined epitopes of the hepatitis B Virus (HBV) core region is associated with HBV disease progressionPMID 22012714Read ↗

CD8+ T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress.Semantic proximity Read ↗

Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression.Semantic proximity Read ↗

Naturally occurring hepatitis B virus core gene mutations.Semantic proximity Read ↗

CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA.Semantic proximity Read ↗

Mutations of hepatitis B virus liver disease.Semantic proximity Read ↗

Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: correlation with viral serotypes and clinical stages of liver disease.Semantic proximity Read ↗

Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen.Semantic proximity Read ↗

Core Antigen Mutations of Human Hepatitis B Virus in Hepatomas Accumulate in MHC Class II-Restricted T Cell EpitopesSemantic proximity Read ↗

The role of mutations in core protein of hepatitis B virus in liver fibrosis.Semantic proximity Read ↗

A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics.Semantic proximity Read ↗

Hepatitis B Virus Core Protein Mutations Are Concentrated in B Cell Epitopes in Progressive Disease and in T Helper Cell Epitopes during Clinical RemissionSemantic proximity Read ↗

Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.