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Article

Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets.

Journal of affective disorders - 1 Feb 2025

Hong Yanggang, Wang Yi, Shu Wanyi

Abstract excerpt

BACKGROUND: Neuroticism, known for its association with a greater risk of psychiatric conditions such as depression and anxiety, is a critical focus of research. METHODS: Cis-expression quantitative trait loci (eQTLs) from 31,684 whole blood samples provided by the eQTLGen Consortium, alongside data from a large neuroticism cohort, were analyzed to identify genes causally linked to neuroticism. To further explore...

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Drug Repositioning
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Neuroticism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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PMID: 39491682
DOI: 10.1016/j.jad.2024.11.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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