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Article

N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression.

Scientific reports - 25 Jun 2018

Matsumoto Gen, Inobe Tomonao, Amano Takanori, Murai Kiyohito, Nukina Nobuyuki, Mori Nozomu

Abstract excerpt

Accumulation of ubiquitinated protein aggregates is a common pathology associated with a number of neurodegenerative diseases and selective autophagy plays a critical role in their elimination. Although aging-related decreases in protein degradation properties may enhance protein aggregation, it remains unclear whether proteasome dysfunction is indispensable for ubiquitinated-protein aggregation in...

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Identifiers

PMID: 29941919
DOI: 10.1038/s41598-018-27872-6
PMCID: PMC6018635

Genes

SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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