Article
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.
Human molecular genetics - 1 Feb 2008
Tan Jeanne M M, Wong Esther S P, Kirkpatrick Donald S, Pletnikova Olga, Ko Han Seok, Tay Shiam-Peng, Ho Michelle W L, Troncoso Juan, Gygi Steven P, Lee Michael K, Dawson Valina L, Dawson Ted M, Lim Kah-Leong
Abstract excerpt
Although ubiquitin-enriched protein inclusions represent an almost invariant feature of neurodegenerative diseases, the mechanism underlying their biogenesis remains unclear. In particular, whether the topology of ubiquitin linkages influences the dynamics of inclusions is not well explored. Here, we report that lysine 48 (K48)- and lysine 63 (K63)-linked polyubiquitination, as well as monoubiquitin modification...
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