Article
Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein.
Human molecular genetics - 1 Apr 2003
Taylor J Paul, Tanaka Fumiaki, Robitschek Jon, Sandoval C Miguel, Taye Addis, Markovic-Plese Silva, Fischbeck Kenneth H
Abstract excerpt
Expression of misfolded protein in cultured cells frequently leads to the formation of juxtanuclear inclusions that have been termed 'aggresomes'. Aggresome formation is an active cellular response that involves trafficking of the offending protein along microtubules, reorganization of intermediate filaments and recruitment of components of the ubiquitin proteasome system. Whether aggresomes are benevolent or...
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