Article
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.
The Journal of cell biology - 10 Sept 2007
Olzmann James A, Li Lian, Chudaev Maksim V, Chen Jue, Perez Francisco A, Palmiter Richard D, Chin Lih-Shen
Abstract excerpt
Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means that cells use to minimize misfolded protein-induced cytotoxicity. However, the molecular mechanism by which misfolded proteins are recruited to aggresomes remains unclear. Mutations in the E3 ligase parkin cause autosomal recessive Parkinson's disease that is devoid of Lewy bodies, which are similar to aggresomes....
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