Host genetic determinants of HTLV-1 infection outcomes.

doi:10.1007/s12026-026-09833-8

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Article

Host genetic determinants of HTLV-1 infection outcomes.

Immunologic research - 26 Aug 2026

Akbarin Mohammad Mehdi, Farjami Zahra, Álvarez Hugo Ramírez

Abstract excerpt

Human T-cell lymphotropic virus type 1 (HTLV-1) is a persistent human retrovirus associated with severe outcomes, most notably adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite lifelong infection, only a minority of carriers develop clinical disease, highlighting a decisive role for host genetic background in shaping viral control, immune...

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