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Article

How do K-RAS-activated cells evade cellular defense mechanisms?

Oncogene - 18 Feb 2016

Lee Y-S, Bae S-C

Abstract excerpt

Lung adenocarcinomas, like other cancers, develop through the accumulation of epigenetic and genetic alterations. Numerous studies have shown that K-RAS mutation is among the most important early events in carcinogenesis of the lung. However, it is also well established that growth-stimulating signals feed back into growth-suppressing pathways, and any imbalance in these signaling networks will cause the cell to...

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Identifiers

PMID: 25961920
DOI: 10.1038/onc.2015.153
PMCID: PMC4761642

Genes

RUNX3

Provenance

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