Deletion of the stress‐response protein REDD1 promotes ceramide‐induced retinal cell death and JNK activation

Abstract excerpt

The role of dyslipidemia in the development of retinal dysfunction remains poorly understood. Using an animal model of diet-induced obesity/pre-type 2 diabetes, we investigated molecular defects in the retina arising from consumption of a diet high in saturated fats and sugars ( i.e., a Western diet). We found that feeding mice a Western diet increased the abundance of retinal sphingolipids, attenuated protein...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endoplasmic Reticulum Stress and Disease
• Share to Retinal Diseases and Treatments
• Share to Sphingolipid Metabolism and Signaling