Article

Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress

2020-06-02

Abstract excerpt

<h4>Summary</h4> Disruption of sphingolipid homeostasis has been shown to cause neurological disorders. How specific sphingolipid species modulate the pathogenesis remains unknown. The last step of sphingolipid de novo synthesis is the conversion of dihydroceramide to ceramide catalyzed by dihydroceramide desaturase (human DEGS1; Drosophila Ifc). Loss of ifc leads to dihydroceramide accumulation and oxidative...

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Literature Corpus work: 2be952a5-2c27-5c72-9302-01594c8ec657
DOI: 10.1101/2020.06.01.128579

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