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Light-dependent induction of <i>Edn2</i> expression and attenuation of retinal pathology by endothelin receptor antagonists in <i>Prominin-1</i> - deficient mice

2020-12-07

Abstract excerpt

Retinitis pigmentosa (RP) and macular dystrophy (MD) are prevalent retinal degenerative diseases associated with gradual photoreceptor death. These diseases are often caused by genetic mutations that result in degeneration of the retina postnatally after it has fully developed. The Prominin-1 gene ( Prom1 ) is a causative gene for RP and MD, and Prom1 - knockout (KO) mice recapitulate key features of these dise...

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Literature Corpus work
1a382527-d916-5a13-92aa-1daea5fcdae4
DOI
10.1101/2020.12.07.405308
Open publication

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