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SMDesigner: a program to design sequence mutations to assess RNA structure.

RNA (New York, N.Y.) - 16 Jun 2025

Hou Lijuan, Raies Meryem, N'Diaye Kadidia Dite Selly, Perreault Jonathan

Abstract excerpt

The structure of RNA is critical to its function. The advancement of structure prediction algorithms and deep sequencing technology has led to the discovery of numerous conserved RNA structures. However, functional analysis of these sequences is lagging behind the rate of novel RNAs' predictions. Traditionally, mutations are designed to alter the structure of RNA and tested individually to assess function. We...

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PMID: 40210487
DOI: 10.1261/rna.080267.124
PMCID: PMC12170191

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