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Article

The effect of APOE genotype on Alzheimer's disease risk is influenced by sex and docosahexaenoic acid status.

Neurobiology of aging - 1 Sept 2018

Pontifex Matthew, Vauzour David, Minihane Anne-Marie

Abstract excerpt

An apolipoprotein E ε4 (APOE-ε4) genotype is the strongest common genetic determinant of Alzheimer's disease (AD). The pleiotropic nature of apolipoprotein E has made elucidation of the aetiological basis difficult to establish, which is further complicated by the fact that the penetrance of the APOE-ε4 allele is modulated by sex, age, and nutrition. A greater metabolic consequence of the APOE-ε4 allele is likely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29909178
DOI: 10.1016/j.neurobiolaging.2018.05.017

Genes

APOE

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