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Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia

16 Jun 2018

Abstract excerpt

OBJECTIVE: Previous gene expression analysis identified a network of coexpressed genes that is associated with β-amyloid neuropathology and cognitive decline in older adults. The current work targeted influential genes in this network with quantitative proteomics to identify potential novel therapeutic targets. METHODS: Data came from 834 community-based older persons who were followed annually, died, and...

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Share to Advanced Proteomics Techniques and Applications
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PMID: 29908079
DOI: 10.1002/ana.25266

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