Article

Molecular Crossroads: Shared and Divergent Molecular Signatures in Alzheimer’s Disease and Dementia with Lewy Bodies

2025-10-31

Abstract excerpt

Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are the two most common forms of dementia due to neurodegeneration. AD is characterized by extracellular amyloid‑β (Aβ) plaques and intracellular tau neurofibrillary tangles, whereas DLB is defined by α‑synuclein (α‑Syn)–containing Lewy bodies. Although AD and DLB exhibit divergent core features, the disorders frequently co‑occur and converge on shared e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa914ae2-f4cf-5a50-98fc-e1d88b0cd7f4
DOI: 10.20944/preprints202510.2504.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular Crossroads: Shared and Divergent Molecular Signatures in Alzheimer’s Disease and Dementia with Lewy BodiesDOI 10.20944/preprints202510.2504.v1Read

Alzheimer’s Disease: Molecular Mechanisms of the Disease and Involved Factors — A Comprehensive Narrative ReviewSemantic proximity Read

Proteomic Insight Into Alzheimer's Disease Pathogenesis PathwaysSemantic proximity Read

Clinical and pathological examples of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal dementia.Semantic proximity Read

Plasma and CSF proteomic signatures related to Alzheimer’s, α-synuclein, or vascular pathologies and clinical declineSemantic proximity Read

Brain cross-omics integration in Alzheimer’s diseaseSemantic proximity Read

Navigation Between Alzheimer’s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology—Genetics and NeuroinflammationSemantic proximity Read

Blood-Based Biomarkers in Alzheimer's Disease: Advancing Non-Invasive Diagnostics and PrognosticsSemantic proximity Read

Spotlight on the Pathophysiological Trajectories Linked to Alzheimer’s Disease (AD): Blood-Brain Barrier (BBB); Neuroinflammation; APOE4 Allele and AD- Insulin Resistance (IR) Pathogenic LinkSemantic proximity Read

The genetic architecture of dementia risk: how Alzheimer’s disease vulnerability converges on lipid metabolism and immune cell networksSemantic proximity Read

Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s diseaseSemantic proximity Read

Proteomic landscape of Alzheimer’s disease: emerging technologies, advances and insights (2021 – 2025)Semantic proximity Read

Shared genes and pathways in dementia: Insights from genome-wide association studies.Semantic proximity Read