Article
Proteomic analysis of the brain in Alzheimer's disease: molecular phenotype of a complex disease process.
Proteomics - 1 Dec 2001
Schonberger S J, Edgar P F, Kydd R, Faull R L, Cooper G J
Abstract excerpt
Alzheimer's disease (AD) is a progressive neurodegenerative disorder accounting for about 50% of all dementias, yet its pathogenic mechanisms remain poorly understood. In order to provide a more complete picture of pathogenesis in AD, we analysed six human brain regions for alterations in their proteomes. Quantitative proteome analysis was used to compare signals corresponding to individual proteins between post...
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