Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

5-Formylcytosine mediated DNA-protein cross-links block DNA replication and induce mutations in human cells.

Nucleic acids research - 27 Jul 2018

Ji Shaofei, Fu Iwen, Naldiga Spandana, Shao Hongzhao, Basu Ashis K, Broyde Suse, Tretyakova Natalia Y

Abstract excerpt

5-Formylcytosine (5fC) is an epigenetic DNA modification introduced via TET protein-mediated oxidation of 5-methyl-dC. We recently reported that 5fC form reversible DNA-protein conjugates (DPCs) with histone proteins in living cells (Ji et al. (2017) Angew. Chem. Int. Ed., 56:14130-14134). We now examined the effects of 5fC mediated DPCs on DNA replication. Synthetic DNA duplexes containing site-specific DPCs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosine
Share to DNA
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to HEK293 Cells

Share to Histones

Share to Molecular Dynamics Simulation

Share to Peptides

Source

Open in PubMed Open full text

Identifiers

PMID: 29905846
DOI: 10.1093/nar/gky444
PMCID: PMC6061883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

5-Formylcytosine mediated DNA-protein cross-links block DNA replication and induce mutations in human cells.PMID 29905846Read ↗

Translesion Synthesis Past 5-Formylcytosine-Mediated DNA-Peptide Cross-Links by hPolη Is Dependent on the Local DNA Sequence.Semantic proximity Read ↗

5-Formylcytosine mediated DNA-peptide cross-link induces predominantly semi-targeted mutations in both Escherichia coli and human cells.Semantic proximity Read ↗

Enzymatic bypass of an N6-deoxyadenosine DNA-ethylene dibromide-peptide cross-link by translesion DNA polymerases.Semantic proximity Read ↗

Replication studies of carboxymethylated DNA lesions in human cells.Semantic proximity Read ↗

Biochemical engineering of 5hmdC-DNA using a Tet3 double-mutantSemantic proximity Read ↗

Translesion synthesis of O4-alkylthymidine lesions in human cells.Semantic proximity Read ↗

Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate ExtenderSemantic proximity Read ↗

EGFP Reporters for Direct and Sensitive Detection of Mutagenic Bypass of DNA Lesions.Semantic proximity Read ↗

Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cells.Semantic proximity Read ↗

Bypass of Mutagenic O(6)-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases.Semantic proximity Read ↗

Cytotoxic and mutagenic properties of alkyl phosphotriester lesions in Escherichia coli cells.Semantic proximity Read ↗

Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.