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Translesion Synthesis Past 5-Formylcytosine-Mediated DNA-Peptide Cross-Links by hPolη Is Dependent on the Local DNA Sequence.

Biochemistry - 15 Jun 2021

Thomforde Jenna, Fu Iwen, Rodriguez Freddys, Pujari Suresh S, Broyde Suse, Tretyakova Natalia

Abstract excerpt

DNA-protein cross-links (DPCs) are unusually bulky DNA lesions that form when cellular proteins become trapped on DNA following exposure to ultraviolet light, free radicals, aldehydes, and transition metals. DPCs can also form endogenously when naturally occurring epigenetic marks [5-formyl cytosine (5fC)] in DNA react with lysine and arginine residues of histones to form Schiff base conjugates. Our previous...

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PMID: 34080848
DOI: 10.1021/acs.biochem.1c00130
PMCID: PMC8586910

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