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Article

Replication studies of carboxymethylated DNA lesions in human cells.

Nucleic acids research - 7 Jul 2017

Wu Jun, Wang Pengcheng, Li Lin, Williams Nicole L, Ji Debin, Zahurancik Walter J, You Changjun, Wang Jianshuang, Suo Zucai, Wang Yinsheng

Abstract excerpt

Metabolic activation of some N-nitroso compounds (NOCs), an important class of DNA damaging agents, can induce the carboxymethylation of nucleobases in DNA. Very little was previously known about how the carboxymethylated DNA lesions perturb DNA replication in human cells. Here, we investigated the effects of five carboxymethylated DNA lesions, i.e. O6-CMdG, N6-CMdA, N4-CMdC, N3-CMdT and O4-CMdT on the efficiency...

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Identifiers

PMID: 28531304
DOI: 10.1093/nar/gkx442
PMCID: PMC5499590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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