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Article

Enzymatic bypass of an N6-deoxyadenosine DNA-ethylene dibromide-peptide cross-link by translesion DNA polymerases.

The Journal of biological chemistry - 1 Jan 2000

Ghodke Pratibha P, Gonzalez-Vasquez Gabriela, Wang Hui, Johnson Kevin M, Sedgeman Carl A, Guengerich F Peter

Abstract excerpt

Unrepaired DNA-protein cross-links, due to their bulky nature, can stall replication forks and result in genome instability. Large DNA-protein cross-links can be cleaved into DNA-peptide cross-links, but the extent to which these smaller fragments disrupt normal replication is not clear. Ethylene dibromide (1,2-dibromoethane) is a known carcinogen that can cross-link the repair protein O6-alkylguanine-DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33617883
DOI: 10.1016/j.jbc.2021.100444
PMCID: PMC8024977

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