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Article

5-Formylcytosine mediated DNA-peptide cross-link induces predominantly semi-targeted mutations in both Escherichia coli and human cells.

The Journal of biological chemistry - 1 Apr 2024

Bacurio Jan Henric T, Yawson Priscilla, Thomforde Jenna, Zhang Qi, Kumar Honnaiah Vijay, Den Hartog Holly, Tretyakova Natalia Y, Basu Ashis K

Abstract excerpt

Histone proteins can become trapped on DNA in the presence of 5-formylcytosine (5fC) to form toxic DNA-protein conjugates. Their repair may involve proteolytic digestion resulting in DNA-peptide cross-links (DpCs). Here, we have investigated replication of a model DpC comprised of an 11-mer peptide (NH2-GGGKGLGK∗GGA) containing an oxy-lysine residue (K∗) conjugated to 5fC in DNA. Both CXG and CXT (where X =...

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Identifiers

PMID: 38401843
DOI: 10.1016/j.jbc.2024.105786
PMCID: PMC10966706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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